abstract：:Neisseria microorganisms (Neisseria lactamica, Neisseria sicca, and Neisseria mucosa) are regarded as normal respiratory commensals. Branhamella catarrhalis (formerly Neisseria catarrhalis) has also been regarded as a normal respiratory commensal, but reports indicate that it can be pathogenic. The role of Neisseria s...

journal_title：Clinical therapeutics

authors： Hamedani P,Hafiz S,Ali J,Memon R,Ali S,Ali M,Ansari M,Siddique I,Raza R

更新日期：1989-09-01 00:00:00

abstract：:The efficacy of cefonicid and of ceftriaxone, administered once daily for the treatment of lower respiratory tract bacterial infections (pneumonia or bronchitis), was evaluated and compared in 118 patients with chronic lung disease. The patients were randomly assigned to receive 1 gm of either drug, intravenously or i...

journal_title：Clinical therapeutics

authors： McCabe RE,Schlossberg D,Donowitz GR,Scheld WM,Zellner SR,Lindenberg LB,Armstrong JH,Ein ME

更新日期：1989-05-01 00:00:00

abstract：:This study was designed to determine changes in the number of beta-adrenergic receptors of circulating lymphocytes in patients with varying degrees of congestive heart failure. Thirty-seven patients with congestive heart failure were classified into four groups according to the functional classifications of the New Yo...

journal_title：Clinical therapeutics

authors： Okada N,Ito T,Satake T

更新日期：1989-05-01 00:00:00

abstract：:Effects of several cerebral metabolic activators on ischemia-induced decrease in brain acetylcholine levels were studied in gerbils. Single administration of lisuride hydrogen maleate (lisuride) significantly inhibited ischemia-induced decreases in acetylcholine in the hippocampus among various regions of the brain in...

journal_title：Clinical therapeutics

authors： Ogawa N,Haba K,Yoshikawa H,Kawata M,Sato H

更新日期：1989-03-01 00:00:00

abstract：:A four-week crossover study to compare the efficacy of an acne cleanser containing 2% salicylic acid with that of a 10% benzoyl peroxide wash was conducted in 30 patients with acne vulgaris. The results demonstrated that only patients treated with the salicylic acid cleanser had a significant reduction in comedones. P...

journal_title：Clinical therapeutics

authors： Shalita AR

更新日期：1989-03-01 00:00:00

abstract：:Of 250 patients undergoing transurethral prostatectomy, 34 had significant bacteriuria after surgery. In 20 patients, including some without significant colonies of bacteria, the same organisms were found before surgery. Closed surgical systems and aseptic techniques can prevent infection from outside the patient, but...

journal_title：Clinical therapeutics

authors： Fujita K

更新日期：1988-01-01 00:00:00

abstract：:Fourteen patients with serious infections caused by Staphylococcus aureus and other gram-positive bacteria were prospectively treated with chromatographically purified vancomycin in an open-label, nonrandomized study, between December 1986 and June 1987. Five patients were excluded from the evaluation of efficacy. Amo...

journal_title：Clinical therapeutics

authors： Wang LS,Liu CY,Wang FD,Fung CP,Chiu ZH,Cheng DL

更新日期：1988-01-01 00:00:00

abstract：:A 28-day regimen of oral contraceptives that uses seven iron tablets (each containing 75 mg of ferrous fumarate) instead of seven sugar placebos was designed to encourage user compliance. To determine professional and user attitudes toward the 28-day regimen, 192 obstetrician-gynecologists and 469 women who used oral ...

journal_title：Clinical therapeutics

authors： Richards-Brandt M

更新日期：1988-01-01 00:00:00

abstract：:Twenty men, aged 50 to 75 years (mean, 67 years), suffering from benign prostatic hypertrophy received 160 mg of a lyposterolic extract of Serenoa repens, twice daily for 30 days. Before and at the end of treatment, plasma levels of testosterone, follicle-stimulating hormone, and luteinizing hormone were determined. N...

journal_title：Clinical therapeutics

authors： Casarosa C,Cosci di Coscio M,Fratta M

更新日期：1988-01-01 00:00:00

abstract：:Absorption of elemental iron from three single-daily-dose prenatal multivitamin/multimineral supplements was compared in bioavailability studies of subjects under fasting and postprandial conditions. Each of the supplements (Stuartnatal 1 + 1, Stuart Prenatal, and Materna 1.60) contained 60 or 65 mg of iron. The subje...

journal_title：Clinical therapeutics

authors： Dawson EB,McGanity WJ

更新日期：1988-01-01 00:00:00

abstract：:The aim of this study was to evaluate the short-term and long-term effects of felodipine, a new dihydropiridine calcium antagonist, on arterial blood pressure (BP), the renin-angiotensin-aldosterone system, diuresis, natriuresis, and the atrial natriuretic factor (ANF). In 15 essential hypertensives (WHO class II) BP,...

journal_title：Clinical therapeutics

authors： Cerasola G,Cottone S,Mangano MT,D'Ignoto G,Pinto A,Carone MB

更新日期：1988-01-01 00:00:00

abstract：:Nicardipine hydrochloride is the first intravenous dihydropyridine calcium antagonist to become available in the United States. Its chemical structure makes it unique among its drug class and confers clinically useful properties for the treatment of acute cardiovascular conditions, such as ischemia, hypertension, cong...

journal_title：Clinical therapeutics

authors： Pepine CJ

更新日期：1988-01-01 00:00:00

abstract：:In a double-blind, randomized study, the clinical effects of 5 mg and 10 mg of cisapride three times daily were compared with those of 10 mg of metoclopramide three times daily in 114 patients with symptoms of gastroesophageal reflux, mainly diurnal and nocturnal heartburn and regurgitation. The symptoms significantly...

journal_title：Clinical therapeutics

authors： Arabehety JT,Leitão OR,Fassler S,Olarte M,Serrano C

更新日期：1988-01-01 00:00:00

abstract：:The efficacy, acceptability, and tolerability of tioconazole solution (1%) in a pump spray were evaluated in an open-label trial in 26 patients with dermatophytosis, superficial candidiasis, and tinea versicolor. Medication was applied twice daily for 30 consecutive days. Eighteen patients had dermatophyte lesions: fo...

journal_title：Clinical therapeutics

authors： del Palacio Hernanz A,Lopez Gomez S,Iglesias Diez L

更新日期：1987-01-01 00:00:00

abstract：:In the past decade surgeons and sex therapists have given an enormous amount of attention to and assistance for men's sexual problems. Now pharmacological help, although controversial, is also available, both informally and from physicians. Sexual disorders afflict men in all walks of life, be they executives or windo...

journal_title：Clinical therapeutics

authors： Renshaw DC

更新日期：1987-01-01 00:00:00

abstract：:A large-scale postmarketing survey was conducted in the United States to evaluate the antihypertensive efficacy and safety of a combination of 50 mg of the long-acting cardioselective beta-blocker atenolol and 25 mg of the monosulfonamyl diuretic chlorthalidone. The program included 28,585 patients (of whom 26,892 pro...

journal_title：Clinical therapeutics

authors： Maxwell MH,Garrett BN,Saunders E,Schnaper H

更新日期：1987-01-01 00:00:00

abstract：:Encapsulation affects the virulence and survival of anaerobic bacteria and their protection from phagocytosis. More encapsulated Bacteroides strains and anaerobic and facultative gram-positive cocci are isolated from patients with clinical infections than from healthy people. The pathogenicity of Bacteroides, Fusobact...

journal_title：Clinical therapeutics

authors： Brook I

更新日期：1987-01-01 00:00:00

abstract：:Forty women with moderate to severe primary dysmenorrhea participated in a two-month, double-blind, crossover trial comparing ketoprofen with mefenamic acid. Treatment with ketoprofen provided rapid and marked pain relief similar to that afforded by mefenamic acid. This improvement in symptoms was accompanied by an am...

journal_title：Clinical therapeutics

authors： Hébert JG,Le Morvan P,Bourgouin J

更新日期：1986-01-01 00:00:00

abstract：:Possible changes in the kinin-prekallikrein system after infusion of factor VIII concentrate were studied in seven patients with severe hemophilia. The functional and immunological activities of factors XI and XII, prekallikrein, high molecular weight kininogen, and C-1-esterase inhibitor were measured before and at 0...

journal_title：Clinical therapeutics

authors： Alegre A,Alberca I,Vicente V

更新日期：1986-01-01 00:00:00

abstract：:Twenty-six women (aged 26 to 60) with stress incontinence underwent urodynamic investigation before and after oral administration of 5 mg of midodrine, a new adrenergic agent with alpha-stimulant activity. A significant increase in maximum urethral closing pressure combined with a nonsignificant increase in flow time ...

journal_title：Clinical therapeutics

authors： Garofalo F,Lalanne GM,Nanni G

更新日期：1986-01-01 00:00:00

abstract：:The effects on corneal tissue of three marketed beta-blocker eye drops, carteolol 1% and 2%, befunolol 0.5% and 1%, and timolol 0.25% and 0.5%, were studied by instilling these drops into the eyes of rabbits twice daily for two consecutive months. The corneal sections were examined under a scanning electron microscope...

journal_title：Clinical therapeutics

authors： Segawa K,Nagai T,Tanaka N,Nishiyama K

更新日期：1986-01-01 00:00:00

abstract：:The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. For the remaining 33 children, levels we...

journal_title：Clinical therapeutics

authors： Crespi HG

更新日期：1986-01-01 00:00:00

abstract：:The long-term tolerability and efficacy of indomethacin were evaluated in a retrospective study of 67 patients with moderate to severe rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis who took the drug daily for periods ranging from three to 20 years. Only patients who had not experienced side effects d...

journal_title：Clinical therapeutics

authors： Lockie LM

更新日期：1986-01-01 00:00:00

abstract：:Forty patients with symptoms of rheumatoid arthritis were treated with daily injections of 100 micrograms of human leukocyte interferon or saline placebo. Twenty patients received the interferon for nine weeks and were then switched to placebo for nine weeks, and 20 patients were started on placebo and were then switc...

journal_title：Clinical therapeutics

authors： Peddinani MV,Savery F,Hang LM

更新日期：1986-01-01 00:00:00

abstract：:Pregnancy creates a climate favorable to the growth of Candida albicans, and this yeast often is difficult to eradicate in pregnant women. Miconazole nitrate administered intravaginally has been found to achieve comparable therapeutic and mycological cure rates in both pregnant and nonpregnant women. A number of clini...

journal_title：Clinical therapeutics

authors： Weisberg M

更新日期：1986-01-01 00:00:00

abstract：:Two studies were conducted to determine the prevalence of Chlamydia trachomatis in the urine and cervical exudates of women with genitourinary symptoms. In the first study, 873 women attending the World Health Organization-Sexually Transmitted Disease Center of the Alfred Fournier Institute, in Paris, were examined. I...

journal_title：Clinical therapeutics

authors： Bohbot JM,Catalan F,Sednaoui P,Siboulet A,Siboulet A

更新日期：1986-01-01 00:00:00

abstract：:The increasing worldwide recognition of the deleterious sequelae of Chlamydia trachomatis urogenital tract infections makes rapid, inexpensive diagnostic tests a high priority. Cell culture, still the standard for all other methods, is only 90% sensitive. Direct fluorescent antibody (FA) tests use highly specific mono...

journal_title：Clinical therapeutics

authors： Thompson SE

更新日期：1986-01-01 00:00:00

abstract：:A double-blind, randomized, placebo-controlled trial was undertaken to evaluate the effect of penicillin on the pneumococcal carrier state of 32 men with chronic bronchitis. Treatment consisted of 250-mg phenoxymethyl penicillin or placebo tablets taken by mouth twice daily for periods of one to three years. Penicilli...

journal_title：Clinical therapeutics

authors： Haas H,Morris JF,Samson S

更新日期：1986-01-01 00:00:00

abstract：:This paper presents a state-of-the-art review of oral contraceptives (OCs), termed one of the epochal developments of modern times. OCs have had both direct and indirect influences on moral, social, and cultural values and on the interaction of population resources and the environment. In recent years there has been...

journal_title：Clinical therapeutics

authors： Greenblatt RB

更新日期：1985-01-01 00:00:00

abstract：:Twenty-seven Escherichia coli test strains that were not susceptible to cephalothin were tested for susceptibility to cefazolin, cefamandole, and ceforanide. By zone-size criteria (greater than or equal to 18 mm), 67% of E coli were susceptible to cefazolin and cefamandole, and 93% were susceptible to ceforanide. By m...

journal_title：Clinical therapeutics

authors： Greenberg RN,Bollinger M

更新日期：1985-01-01 00:00:00

abstract：:Hemodynamic and electrophysiologic effects of procainamide, the pharmacokinetic properties of conventional and sustained-release forms of the drug, guidelines for its administration and dosage, and contraindications for and adverse effects of its use are outlined. A review of clinical studies of procainamide therapy c...

journal_title：Clinical therapeutics

authors： Anderson JL

更新日期：1985-01-01 00:00:00

abstract：:A single 5-gm dose of mezlocillin or a placebo was administered intravenously 30 minutes before surgery to patients undergoing emergency cesarean section. The assignment of drug or placebo was randomized. Postoperative morbidity occurred in 62.5% of patients receiving placebo and in 18.4% of those receiving mezlocilli...

journal_title：Clinical therapeutics

authors： Jaffe R,Altaras M,Cohen I,Ben-Aderet N

更新日期：1985-01-01 00:00:00

abstract：:We studied the effects of atropine and pirenzepine on acid secretion induced by electrical vagal stimulation (EVS) and on healing of gastric ulcers after mucosal excision in rats. Both atropine (50, 125, and 250 micrograms/kg/hr) and pirenzepine (2.5, 5.0, and 12.5 mg/kg/hr), administered intraperitoneally, inhibited ...

journal_title：Clinical therapeutics

authors： Sano M,Kitagawa H,Fujiwara M

更新日期：1985-01-01 00:00:00

abstract：:An open clinical trial with prifinium bromide, an anticholinergic agent, was carried out in 21 patients with irritable bowel syndrome showing clear psychosomatic characteristics. The clinical efficacy was evaluated by comparing the symptomatic severity before, during, and after treatment with prifinium bromide, 90 mg/...

journal_title：Clinical therapeutics

authors： Sasaki T,Takekoshi T,Okada T

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5 micrograms/ml, and...

journal_title：Clinical therapeutics

authors： Stile IL,Simon R,Hiatt IM,Hegyi T

更新日期：1985-01-01 00:00:00

abstract：:The added hypotensive effect of bevantolol, a new cardioselective beta-blocker, was studied in 244 patients with mild to moderate essential hypertension following prior treatment with hydrochlorothiazide or placebo. After four weeks of monotherapy with 50 mg/day or 100 mg/day of hydrochlorothiazide or placebo, the mea...

journal_title：Clinical therapeutics

authors： Lucas CP,Morledge JH,Tessman DK

更新日期：1985-01-01 00:00:00

abstract：:In two multicenter, double-blind studies, ciclopirox olamine cream 1% was compared with either its cream vehicle or with 1% clotrimazole cream for the treatment of patients with tinea pedis. Evaluations were made before treatment, weekly for four weeks during treatment, and for two weeks posttreatment. Ciclopirox olam...

journal_title：Clinical therapeutics

authors：

更新日期：1985-01-01 00:00:00

abstract：:Chemotherapy with doxorubicin often leads to congestive heart failure, particularly after cumulative doses of 550 mg/m2 have been reached. Certain risk factors, however, may predispose the patient to development of cardiomyopathy at lower doses. Radionuclide ventriculography with determinations of resting and exercise...

journal_title：Clinical therapeutics

authors： Steinberg JS,Wasserman AG

更新日期：1985-01-01 00:00:00

abstract：:One hundred sixteen children between 2 and 15 years of age entered a clinical trial of albendazole after examination of their stools revealed ova of one or more intestinal helminths. The drug was administered as a single 400-mg dose (20 ml of 2% suspension) to all the patients except those having Hymenolepis nana infe...

journal_title：Clinical therapeutics

authors： Prasad R,Mathur PP,Taneja VK,Jagota SC

更新日期：1985-01-01 00:00:00

abstract：:Serum creatinine and beta 2-microglobulin levels, endogenous creatinine clearance, the urinary beta 2-microglobulin excretion rate, and urinary protein levels were monitored serially in 29 patients with duodenal ulcers randomly allocated to receive eight weeks of treatment with cimetidine, ranitidine, or an antacid. A...

journal_title：Clinical therapeutics

authors： Yeung CK,Wong KL,Ng MT,Lai CL

更新日期：1984-01-01 00:00:00